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Year : 2015  |  Volume : 1  |  Issue : 1  |  Page : 12-15

Role of clofazimine in management of reactions in leprosy: A brief overview

Director, Bombay Leprosy Project, Mumbai, Maharashtra, India

Correspondence Address:
V V Pai
Bombay Leprosy Project, Vidnyan Bhavan, 11, VN Purav Marg, Sion.-Chunabhatti, Mumbai - 400 022, Maharashtra
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/WKMP-0110.170761

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Clofazimine is a synthetic dye that has been used in the treatment of leprosy since many years. Its role in the treatment of lepra reactions was subsequently recognized. When the dose of 300 mg/day is used, it doubles the serum concentration of the drug and supposedly exerts potent anti-neutrophilic effect and inhibits of prostaglandins. Our personal experience with high dosages of clofazimine in type II lepra reactions and review of the literature suggests that clofazimine has been extremely useful in providing good and satisfactory results in leprosy patients suffering from these embarrassing conditions. The anti-inflammatory effect of clofazimine is greatly useful in managing recurrent and chronic type II reactions with its steroid-sparing effect and providing an alternate and in expensive option.

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