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Year : 2018  |  Volume : 4  |  Issue : 1  |  Page : 7-12

Comparision of oral levofloxacin and minocycline in treatment of inflammatory acne vulgaris: A randomized control trial

1 Department of Dermatology, Smt Kashibai Navale Medical College and Gen Hospital, Pune, Maharashtra, India
2 Consultant Dermatologist and Dermato-Pathologist, Tilak Road, Pune, Maharashtra, India

Correspondence Address:
Dr. Swapna Khatu Sheth
Department of Dermatology, Smt Kashibai Navale Medical College, OPD No 6, Bldg No 1, Pune, Maharashtra
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijdd.ijdd_21_17

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Background: Acne vulgaris is a chronic inflammatory disease of pilosebaceous units. This disease occurs worldwide and usually starts in adolescence and resolves by mid-twenties. It is the most common skin disorder, and different studies have shown prevalence rates ranging from 28.9% to 91.3% in adolescents. Aims: The aim of this study is to assess, compare, and correlate therapeutic efficacy of oral levofloxacin and minocycline combine with benzoyl peroxide gel in the treatment of acne vulgaris. Methods: The study comprised 60 acne vulgaris patients. They were allotted randomly in two groups, 30 in each group. Baseline investigations were performed at 1st visit. Baseline photographs were taken. Levofloxacin was given at dose of 500 mg/day for 30 days along with topical benzoyl peroxide gel in one group, and another group received minocycline 100 mg for 3 months along with topical benzoyl peroxide gel. Results were assessed at 2, 4, 8, and 12 weeks after starting treatment according to the global acne grading system and compared with each other statistically using t-test. Results: There was a significant decrease in acne score in levofloxacin group as compared to minocycline group. (P = 0.05) at 4 weeks. At 8 weeks and 12 weeks, decrease in the score was more in minocycline group (P < 0.024) and (P < 0.001), respectively. According to the percentage of decrease in inflammatory count from baseline, there was a decrease in inflammatory lesion count by 58% at 4 weeks which increased to 81.1% at the end of 12 weeks in levofloxacin group. In minocycline group, a decrease in inflammatory lesion count at 4 weeks was 36.6% and 12 weeks was 68%.

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