| MANAGING A SIDE EFFECT |
|
| Year : 2019 | Volume
: 5
| Issue : 1 | Page : 66-71 |
|
|
Managing a side effect: Cyclophosphamide-induced hemorrhagic cystitis
Bhavana Ravindra Doshi, Vijaya Veeranna Sajjan, BS Manjunathswamy
Department of Dermatology, KLE Academy of Higher Education and Research, JNMC, Belagavi, Karnataka, India
Correspondence Address:
Dr. Bhavana Ravindra Doshi
Department of Dermatology, KLE Academy of Higher Education and Research, JNMC, Belagavi - 590 010, Karnataka
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/ijdd.ijdd_31_19
|
|
|
Cyclophosphamide is a nonphase-specific cytotoxic agent that can kill cells at any phase of the cell cycle. The drug is metabolized by hepatic cytochrome P450 microsomal enzymes, which results in the formation of the active metabolites phosphoramide mustard and acrolein. It is the acrolein which is responsible for hemorrhagic cystitis as a complication of cyclophosphamide therapy. An early diagnosis and prompt management holds the key in its management.
|
|
|
|
| [FULL TEXT] [PDF]* |
|
 |
|
