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Year : 2019  |  Volume : 5  |  Issue : 2  |  Page : 89-93

Assessment of cutaneous adverse drug reactions in a tertiary care hospital

Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy of Higher Education and Research (JSSAHER), Mysuru, Karnataka, India

Correspondence Address:
Dr. Madhan Ramesh
Department of Pharmacy Practice, JSS College of Pharmacy, JSSAHER, Sri Shivarathreeshwara Nagar, Mysuru - 570 015, Karnataka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijdd.ijdd_6_18

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Introduction: Cutaneous adverse drug reactions (CADRs) are one of the significant clinical problems not only in dermatology practice but also in any areas where drug is involved. Aim: The aim of this study was to determine the incidence, pattern, predictors, and direct cost associated with the management of CADRs. Methodology: It was a prospective, observational study which involved both spontaneous reporting and intensive monitoring. Study patients were followed throughout their hospital stay. Where a CADR was detected, all the required data were collected and analyzed. Bivariate regression analysis was used to determine the predictors of CADRs. Results: The incidence of CADRs was 25.01%. Drug classes most commonly implicated in CADRs were antibiotics (29.055%), nonsteroidal anti-inflammatory drugs (17.31%), antineoplastic drugs (11.17%), and antitubercular drugs (10.05%). Majority (66.48%) of the reactions were “probable” in their causality category. Serious CADRs accounted for 1.67%. There was a significant association between the occurrence of CADRs and the use of ≥2 medications, adult patients, and male gender. The total and average costs incurred in the management of CADRs were INR 61,116/- and 734/-, respectively. Conclusion: Among the study population, adults, male gender, and patients receiving ≥2 medications and patients who presented with ≥2 comorbidities were identified as the predictors for the development of CADRs. Hence, it is important to monitor closely the patients with the identified risk factors for the CADRs to minimize the complications associated with the CADRs.

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