A retrospective analysis of real-world data to evaluate the safety and effectiveness of topical amorolfine in tinea infection

Devendra Jain; Pradeep Kumar; Sanjib Chowdhuri; Hitesh Doshi; Umesh Jain; Savitha L Beergouder; Krishnasree Maganti; Rashmi Rani; Bhagyashree Mohod; Ashok Jaiswal

doi:10.4103/ijdd.ijdd_8_22

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ORIGINAL ARTICLE

Year : 2022 | Volume : 8 | Issue : 2 | Page : 66-72

A retrospective analysis of real-world data to evaluate the safety and effectiveness of topical amorolfine in tinea infection

Devendra Jain¹, Pradeep Kumar², Sanjib Chowdhuri³, Hitesh Doshi⁴, Umesh Jain⁵, Savitha L Beergouder⁶, Krishnasree Maganti⁷, Rashmi Rani⁸, Bhagyashree Mohod⁹, Ashok Jaiswal⁹
¹ Prathama Skin and Hair Care Center, Virar, Maharashtra, India
² Skin Care Center, Gandhinagar, Ghaziabad, Uttar Pradesh, India
³ Fortis Hospital, Anandapur & Wizderm Skin & Hair Clinics, Kolkata, West Bengal, India
⁴ Sardar Smarak Hospital & Muslim Trust Hospital, Surat, Gujarat, India
⁵ Dermacure Advanced Skin and Hair Clinic, Mayur Vihar, Delhi, India
⁶ Anagha Skin and Hair Clinic, Bagalkot, Karnataka, India
⁷ Maganti Hospital, Gudivada, Andhra Pradesh, India
⁸ Sadar Hospital, Jamuhar, Bihar, India
⁹ Medical Affairs Department, Zydus Healthcare Ltd., Mumbai, Maharashtra, India

Correspondence Address:
Bhagyashree Mohod
Medical Affairs Department, Zydus Healthcare, ‘Zydus Tower’ CTS No. 460/6,Village Pahadi, Off I. B. Patel Road, Goregaon East, Mumbai 400063, Maharashtra
India

Source of Support: None, Conflict of Interest: None

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DOI: 10.4103/ijdd.ijdd_8_22

Background: Conventional antifungals are becoming resistant against dermatophytosis due to development of recalcitrant tinea. These patients may get benefit from newer topical antifungals or combination therapy. Topical antifungal therapy is the mainstay in the treatment of dermatophytosis. Aims/Objectives: To evaluate the safety and effectiveness of topical amorolfine in tinea infection in real-world settings. Materials and Methods: This was a real-world retrospective study; data was collected from 106 centers across India on the usage of amorolfine in the management of tinea infections. The treatment response was evaluated at the end of 2 and 4 week. It was determined by the reduction in severity of the classic symptoms of disease viz. pruritus, burning sensation, erythema, and scaling and crusting at Week 2 and Week 4 of treatment. The severity of symptoms was classified and quantified as mild (1), moderate (2), and severe (3). Safety was determined based on the occurrence of any adverse events during the treatment. Results: An improvement in symptoms score was observed for all the classic symptoms of infection viz. pruritus, burning sensation, erythema, and scaling and crusting at Week 2 and Week 4 compared to baseline. Mean total symptom score (TSS) was reduced to 0.88 ± 1.19 from 7.18 ± 2.84 at week 4 (P < 0.05). Only 10 (0.73%) patients out of 1358 showed mild and non-treatment-related adverse events. Conclusion: Amorolfine alone or in combination therapy with oral antifungals in real world clinical setting represents an improved treatment strategy for patients with tinea infections.

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