• Users Online: 8502
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Reader Login
Export selected to
Endnote
Reference Manager
Procite
Medlars Format
RefWorks Format
BibTex Format
  Citation statistics : Table of Contents
   2017| January-June  | Volume 3 | Issue 1  
    Online since June 27, 2017

 
 
  Archives   Previous Issue   Next Issue   Most popular articles   Most cited articles
 
Hide all abstracts  Show selected abstracts  Export selected to
  Cited Viewed PDF
REVIEW ARTICLES
Itraconazole: What clinicians should know?
Piet De Doncker, Sushil Pande, Ute Richarz, Nishant Garodia
January-June 2017, 3(1):4-10
DOI:10.4103/ijdd.ijdd_20_17  
Our purpose in assembling this paper is 2-fold. First, we hope to review in-depth the properties on itraconazole pellet-capsules and what clinicians should know when considering oral itraconazole and discuss the potential value of treating superficial dermatophyte infections with oral antifungal therapy. Second, we hope to address some of the concerns of the recent epidemic of chronic recalcitrant widespread dermatophytosis in India, with emphasis on better treatment but also considering some of the necessary prophylaxis hygiene measures. An in-depth review of itraconazole (as pellet-capsules), a triazole antifungal will be presented with focus on the pharmacokinetic properties which lead to the development of the 1-week pulse dosing for skin and nail infections. Finally, recommendations for best usage of itraconazole pellet-capsules for management of dermatophytosis will be summarized in this paper.
  24 24,856 1,854
EDITORIAL
Clinical failure of antifungal therapy of dermatophytoses: Recurrence, resistance, and remedy
Ragunatha Shivanna, Arun C Inamadar
January-June 2017, 3(1):1-3
DOI:10.4103/ijdd.ijdd_13_17  
  9 13,772 1,054
ORIGINAL ARTICLES
Effect of measles mumps rubella vaccine in treatment of common warts
Anuja Dhope, Bhushan Madke, Adarsh Lata Singh
January-June 2017, 3(1):14-19
DOI:10.4103/ijdd.ijdd_1_17  
Background: There are many destructive and immunotherapeutic options available for the treatment of common warts, but no treatment is 100% effective and usually cause pain and scarring. Recently, intralesional immunotherapy with skin test antigens and vaccines has been shown to be effective in the management of warts. We evaluated the efficacy of Measles Mumps Rubella (MMR) vaccine injection in the treatment of cutaneous warts. Aim: To study the efficacy of intralesional MMR vaccine in the treatment of common warts. Materials and Methods: A case–control study was conducted in AVBR Hospital, Sawangi (Meghe), Wardha, in 2015–2016. Forty clinically diagnosed cases of cutaneous common wart were selected in the study and were put randomly into two groups (20 in each group). Group 1: included twenty patients subjected to intralesional injection of 0.5 ml MMR vaccine. Group 2: included twenty patients as a control group and subjected to intralesional injection of 0.5 ml saline. These injections were repeated every 3 weeks intervals for maximum three injections. Follow-up of patients was done every 6 months for clinical assessment of results and to study recurrence. Results: A significant difference was found between the therapeutic responses of common warts to MMR. Vaccine and normal saline (control) group. At the end of 9 weeks (third visit), about 65% patients treated with MMR vaccine showed complete clearance compared with 5% of the control group. Grade 3 response was 20% versus 10% respectively; whereas Grade 2 response was observed in 10% versus 25%, respectively, and as regards no response, it was 5% versus 60% in MMR vaccine and control group, respectively. Conclusion: We found that the treatment of common warts by MMR vaccine is effective, with good cure rates, and excellent safety profile.
  9 18,716 518
BRIEF REPORT
Successful use of oral acitretin in oral lichen planus
Ajay Deshpande
January-June 2017, 3(1):24-27
DOI:10.4103/ijdd.ijdd_9_17  
Lichen planus is a common inflammatory disorder affecting skin, mucus membranes, nails, and hair. At least two-thirds of cases occur between 30 and 60 years of age. Lichen planus can affect the mucosal surfaces of mouth, genitalia, conjunctiva, esophagus, anus, and urethra. Oral lichen planus is relatively common than lichen planus of other mucosal areas. Oral lichen planus is very refractory to treatment. Oral and topical steroids, topical tacrolimus, azathioprine, cyclosporine, and dapsone are the drugs used to treat oral lichen along with acitretin. We hereby report the successful treatment of oral lichen planus with acitretin in three patients.
  6 12,685 221
LETTERS TO EDITOR
Azathioprine-induced alopecia as an early clinical marker of its myelotoxicity
Anil B Bhokare
January-June 2017, 3(1):40-41
DOI:10.4103/ijdd.ijdd_4_17  
  5 42,062 169
CASE REPORTS
Generalized bullous fixed drug reaction: A close similarity to stevens–johnson syndrome
Bhagyashri Daulatabadkar, Sushil Pande, Milind Borkar
January-June 2017, 3(1):28-31
DOI:10.4103/ijdd.ijdd_11_17  
Generalized bullous fixed drug eruption is bullous type of fixed drug eruption characterized by sharply defined bullae at the same site following administration of offending drug. GBFDE has aggressive course unlike conventional FDE and requires aggressive treatment. Mucosa is usually spared and constitutional symptoms are mild. We came across two cases of GBFDE in which culprit drugs were B-Lactam antibiotics.
  4 14,209 358
ORIGINAL ARTICLES
A clinical study of severe cutaneous adverse drug reactions and role of corticosteroids in their management
Rohini Sharma, Naina Dogra, Devraj Dogra
January-June 2017, 3(1):20-23
DOI:10.4103/ijdd.ijdd_22_16  
Background: Various medications are used for the treatment of various diseases. Ironically, adverse drug reactions (ADRs) also accompany the use of these medications and are as old as the medicine itself. These drug reactions can range from mild transient erythema at one end of the spectrum to severe cutaneous ADRs (SCADRS) that include Steven–Johnson syndrome (SJS), toxic epidermal necrolysis, acute generalized exanthematous pustulosis, and drug reaction with eosinophilia and systemic symptoms complex (DRESS). Aim: This study aims to study the clinical and epidemiological aspects of severe cutaneous adverse drug reactions (SCADRS) at a referral center of Jammu region, with special reference to the role of corticosteroids in the management. Materials and Methods: The study was carried out between July 2015 and December 2015, at a tertiary hospital after permission from Ethical Committee of the institution. A total of 44 patients were included in the study which included outpatients as well as inpatients admitted after written informed consent. The Naranjo ADR probability scale was applied to indicate the causality of the drug with the SCADRS. Results: In the study, a total of 44 patients were included in the study. Males outnumbered the females, and maximum patients were in the age group of 21–40 years. SJS was the most common SCARD found followed by DRESS. Antiepileptic class of drug was found to be most commonly implicated. Immediate withdrawal of the culprit drug and administration of systemic steroids reverted the SCARD in maximum patients. Conclusion: Severe cutaneous adverse drug reactions can be associated with serious morbidity as well as mortality. Their knowledge and prompt recognition are essential for clinicians as early recognition, and immediate withdrawal of the culprit drug/drugs with adequate management can be lifesaving.
  3 5,487 223
TABLE
Maculopapular drug eruption versus maculopapular viral exanthem
Bhavana R Doshi, BS Manjunathswamy
January-June 2017, 3(1):45-47
DOI:10.4103/ijdd.ijdd_19_17  
  2 25,179 962
CASE BASED LEARNING
Maculopapular drug eruption secondary to pyrazinamide
Bhavana Ravindra Doshi, BS Manjunathswamy
January-June 2017, 3(1):53-56
DOI:10.4103/ijdd.ijdd_15_17  
  1 4,629 115
LETTERS TO EDITOR
Urticarial rash after tranexamic acid infusion
Raghavendra Vagyannavar, Rekha Devi, Vandna Bharti
January-June 2017, 3(1):43-44
DOI:10.4103/ijdd.ijdd_5_17  
  1 3,730 69
CASE REPORTS
Pityriasis rosea like eruption possibly due to anti-rabies vaccine administration in a young man: A rare case report
Akhilesh Vilaskumar Thole, Vinod K Khurana, Rachita R Misri, Virender K Gupta
January-June 2017, 3(1):32-34
DOI:10.4103/ijdd.ijdd_13_16  
Pityriasis rosea (PR) is an acute, self-limited skin disease thought to be a viral exanthem caused by reactivation of HHV-7 and HHV-6 viruses; although, numerous studies have explored various pathogens. Several reports associate PR with drugs and vaccines. We report a typical case of PR in a 26-year-old male following intradermal anti-rabies vaccine (ARV). There are reports of vaccine-induced pityriasis like eruptions due to various vaccine. However, PR-like eruptions due to ARV is rarely reported. This case represents a new side effect of an already existing vaccine and throws light on varied etiologies of vaccine-induced PR.
  - 6,794 71
LETTERS TO EDITOR
Levamisole in childhood pemphigus vulgaris
Apurva Aditi, Sushil Pande, Milind Borkar
January-June 2017, 3(1):35-36
DOI:10.4103/ijdd.ijdd_12_17  
  - 3,592 82
Diffuse melanonychia in a patient of chronic plaque psoriasis on hydroxyurea
Bhagyashree Babanrao Supekar, Kinjal Deepak Rambhia, Jayesh Ishwardas Mukhi, Rajesh Pratap Singh
January-June 2017, 3(1):36-38
DOI:10.4103/ijdd.ijdd_10_17  
  - 3,739 61
Fixed drug eruption due to linezolid
Arun C Inamadar, Aparna Palit
January-June 2017, 3(1):38-39
DOI:10.4103/ijdd.ijdd_8_17  
  - 4,574 61
Drug-induced leukocytoclastic cutaneous vasculitis by simvastatin
Amine Mohamed Hamzi, Mohammed Allaoui
January-June 2017, 3(1):41-43
DOI:10.4103/ijdd.ijdd_35_16  
  - 4,898 69
REVIEW ARTICLES
Saw palmetto extract: A dermatologist's perspective
Varshini Reddy, Aditya Kumar Bubna, Mahalakshmi Veeraraghavan, Sudha Rangarajan
January-June 2017, 3(1):11-13
DOI:10.4103/ijdd.ijdd_45_16  
Saw palmetto extract is believed to have antiandrogenic properties and has been used widely for the treatment of androgenic alopecia. It is claimed to have much less side effects as compared to finasteride. Along with its use for androgenic alopecia, it has also been tried for other conditions associated with increased androgen levels in dermatology. This article will review a dermatologist's perspective of this traditional herb.
  - 14,331 336
VIVA VOCE
Use of propranolol in infantile hemangioma
Manish K Shah, Resham J Vasani
January-June 2017, 3(1):48-52
DOI:10.4103/ijdd.ijdd_17_17  
  - 13,885 511
WHAT’S IN NEWS
News from regulatory corner: Safety communication and recent drug approvals
Ajit Barve
January-June 2017, 3(1):57-58
DOI:10.4103/2455-3972.209043  
  - 3,853 100