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  Indian J Med Microbiol
 

Figure 1: Skin injury releases LL37 (cathelicidin), RNA, and DNA which bind to plasmacytoid dendritic cell (pDC) and release INF-α which activates myeloid dendritic cell (mDC). MDC activates naïve T cell through primary signal and co-stimulation. IL-12 and TNF-α secreted by mDC act on activated T cells to form Th1 lineage of cells. IL-23 and TNF-α secreted by mDC act on activated T cells to form Th17 and Th22 lineage of cells. Cytokines INF-γ and TNF-α from Th 1 cells, IL-17 and TNF-α from Th 17 cells, and IL-22 from Th 22 cells lead to keratinocyte activation

Figure 1: Skin injury releases LL37 (cathelicidin), RNA, and DNA which bind to plasmacytoid dendritic cell (pDC) and release INF-α which activates myeloid dendritic cell (mDC). MDC activates naïve T cell through primary signal and co-stimulation. IL-12 and TNF-α secreted by mDC act on activated T cells to form Th1 lineage of cells. IL-23 and TNF-α secreted by mDC act on activated T cells to form Th17 and Th22 lineage of cells. Cytokines INF-γ and TNF-α from Th 1 cells, IL-17 and TNF-α from Th 17 cells, and IL-22 from Th 22 cells lead to keratinocyte activation